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CAS No. : 25389-94-0
MCE 国际站:Kanamycin sulfate
产品活性:Kanamycin (Kanamycin A) sulfate 是一种口服有效的抗菌剂 (革兰氏阴性/阳性细菌),可通过与 70 S 核糖体亚单位结合,抑制转位并导致编码错误。Kanamycin sulfate 对 M. tuberculosis (敏感或耐药) 以及 K. pneumonia 均具有较好的抑制活性,可用于肺结核和肺炎的研究。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 疾病研究 | 抗炎/免疫调剂 | 抗生素 | 其他类 | 抗生素 | 植物细胞培养 | 抗生素 | 哺乳动物细胞培养 | 抗生素 | 抗性筛选 | 结构分类
In Vitro: Kanamycin sulfate (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro.
In Vivo: Kanamycin sulfate (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice.
Kanamycin sulfate (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice.
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