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Daunorubicin hydrochloride

CAS No. : 23541-50-6

MCE 国际站：Daunorubicin hydrochloride

产品活性：Daunorubicin (Daunomycin) hydrochloride 是一种拓扑异构酶 II (topoisomerase II) 抑制剂，具有有效的抗肿瘤活性。Daunorubicin hydrochloride 抑制 DNA 和 RNA 合成 (DNA and RNA synthesis)。Daunorubicin hydrochloride 是一种细胞毒素，可抑制癌细胞活力并诱导细胞凋亡 (apoptosis) 和坏死 (necrosis)。Daunorubicin hydrochloride 还是一种蒽环类抗生素。Daunorubicin hydrochloride 可用于研究感染和多种癌症，包括白血病、非霍奇金淋巴瘤、尤文氏肉瘤、维尔姆斯氏瘤。

研究领域：Cell Cycle/DNA Damage  |  Antibody-drug Conjugate/ADC Related  |  Anti-infection  |  Autophagy  |  Apoptosis

作用靶点：Topoisomerase  |  DNA/RNA Synthesis  |  ADC Cytotoxin  |  Bacterial  |  Autophagy  |  Apoptosis  |  Antibiotic

结构分类：醌类  |  蒽醌类  |  酚类  |  多酚类  |  结构分类

In Vitro: Daunorubicin hydrochloride (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.
Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.
Daunorubicin hydrochloride (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.
Daunorubicin hydrochloride (0.4 μM, 120 min) induces ROS generation in L3.6 cells.
Daunorubicin hydrochloride (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).

In Vivo: Daunorubicin hydrochloride (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.
Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.

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