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CAS No. : 60-82-2
MCE 国际站:Phloretin
产品活性:Phloretin (NSC 407292; RJC 02792) 是一种从苹果中提取的黄酮类化合物,具有抗炎活性。Phloridzin 是一种特异性、竞争性和口服活性的钠/葡萄糖协同转运蛋白 (sodium/glucose cotransporters) 抑制剂,在肠道 (SGLT1) 和肾脏 (SGLT2)。Phloretin 抑制 Yeast-made GLUT1 以及人类红细胞 GLUT1 的 IC50 值分别为 49 μM 和 61 μM。Phloretin 具有潜力用于类风湿性关节炎 (RA) 和过敏性气道炎症的相关研究。
研究领域:Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点:SGLT | Endogenous Metabolite | GLUT
结构分类:黄酮类 | 二氢查耳酮 | 酚类 | 多酚类 | 结构分类
来源:植物 | 蔷薇科 | 苹果
In Vitro: Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 μM.?Phloretin (40-160 μM; 24 hours) induces BEL-7402 cell apoptosis though the mitochondrial pathway, the cells exposed to phloretin exhibits nuclear chromatin condensation and increased fluorescence intensity. The caspase-9 reaches the peak level at 12 h, and leak levels of caspase-6 and caspase-3 activities occurrs 18 and 24 h after the exposure, respectively.?Phloretin (0-100 μM; 24 hours) has effects on transcription factors of adipogenesis in differentiated 3T3-L1 adipocytes, decreases PPAR-γ, C/EBPα and C/EBPβ as a dose-dependent manner.?Phloretin (0-100 μM; 24 hours) has effects on the AMPK pathway in differentiated 3T3-L1 adipocytes, increases the phosphorylation of substrate ACC-1, AMPK in PT-treated cells.
In Vivo: Phloretin (oral administration; 50 or 100?mg/kg; once daily) decreases oxidative stress and diminished levels of malondialdehyde (MDA) and hydrogen peroxide (Phloretin (口服给药;50 或 100 mg/kg;每天一次) 降低爪组织中的氧化应激和丙二醛 (MDA) 和过氧化氢 (H2O2) 的水平,降低血清中抗胶原抗体的生产率。) in paw tissue, reduces productivity of anti-collagen antibodies in serum.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Phenols Library | Glycolysis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Gut Microbial Metabolite Library | Anti-Cancer Metabolism Compound Library | Microbial Metabolite Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Food Additive Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Nicotinamide N-oxide | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Methylmalonic acid | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Sphingomyelin | (-)-Jasmonoyl-L-isoleucine | Octanoic acid-d2 | Mizagliflozin | Vardenafil-d5 | N-Acetyllactosamine | D-Arabitol-13C | Imidazole | L-Tartaric acid diammonium | i-Inositol | Tryptophol | L-Aspartic acid | Indolelactic acid | 6-Mercaptopurine-13C2,15N | D-Sorbitol-d8 | Octanoic acid-d3
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
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