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Bilobalide

CAS No. : 33570-04-6

MCE 国际站：Bilobalide

产品活性：Bilobalide 是银杏叶中的的一种倍半萜三内酯成分，抑制 NMDA 诱导的胆碱流出，IC₅₀ 值为 2.3 µM。Bilobalide 通过激活 SH-SY5Y 细胞中的 PI3K/Akt 通路来防止细胞凋亡 (apoptosis)。对神经元发挥保护和营养作用。

研究领域：Apoptosis  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Autophagy  |  Endogenous Metabolite

结构分类：萜类  |  倍半萜

来源：植物  |  银杏科  |  银杏

In Vitro: Bilobalide (1-100 µM) completely suppresses the NMDA-evoked release of choline in a concentration-dependent manner with IC₅₀ value of 2.3 µM.
Bilobalide (1, 5 and 10 μM) alone for 24 h does not affect cell viability of SH-SY5Y cells. Pre-treatment of cells with Bilobalide concentration-dependently prevents Aβ 1-42-, H₂O₂- and serum deprivation-induced decrease of cell viability, with the best protective effect obtained at 10 μM.
Bilobalide (5 and 10 μM; 24 h) treatment dose-dependently increases levels of p-Akt (Ser473 and Thr308) in SH-SY5Y cells.

In Vivo: Bilobalide (20 mg/kg) completely suppresses the NMDA-induced release of choline in vivo while basal choline levels were not significantly affected. NMDA causes a release of choline in vivo when infused into the hippocampus of freely moving rats by retrograde dialysis. Bilobalide (20 mg/kg i.p.) completely inhibits the effect induced by NMDA.

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