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Vinorelbine ditartrate

CAS No. : 125317-39-7

MCE 国际站：Vinorelbine ditartrate

产品活性：Vinorelbine ditartrate 是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC₅₀值为 1.25 nM。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton  |  Autophagy

作用靶点：Microtubule/Tubulin  |  Autophagy

结构分类：生物碱  |  生物碱二聚体  |  结构分类

来源：植物  |  夹竹桃科  |  长春花

In Vitro: Vinorelbine (0.5-5 nM) ditartrate inhibits cell proliferation by 50% (IC₅₀) at concentrations of 1.25 nM. At a concentration of 8 nM, no cells are in anaphase. Vinorelbine ditartrate time-dependently induces the p53 and p21^WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine ditartrate stimulates reporter genes in a concentration-dependent manner.

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