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CAS No. : 56-12-2
MCE 国际站:γ-Aminobutyric acid
产品活性:γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABAA 受体和促代谢 GABAB 受体结合发挥作用。γ-Aminobutyric acid 能够阻断中枢神经系统的特定信号,并带来镇静效果。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点:GABA Receptor | Endogenous Metabolite
结构分类:酮、醛、酸 | 结构分类
In Vitro: γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM.
Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation.
γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth.
In Vivo: γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice.
γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure.
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