MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CMX-2043

CAS No. : 910627-26-8

MCE 国际站：CMX-2043

产品活性：CMX-2043 是 α-Lipoic Acid (HY-N0492) 新型类似物。CMX-2043 具有抗氧化作用，能够激活胰岛素受体激酶，可溶性酪氨酸激酶，和促 Akt 磷酸化。CMX-2043 在大鼠缺血再灌注损伤 (IRI) 模型中表现出保护作用。

研究领域：Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease  |  PI3K/Akt/mTOR

作用靶点：Insulin Receptor  |  Tyrosinase  |  Akt

In Vitro: CMX-2043 (15-250 mM; 10 min) has great peroxyl radical absorbance capacity.
CMX-2043 (1.5 μM) weakly inhibits spleen tyrosine kinase (Syk) and tunica interna endothelial cell kinase (Tie2).
CMX-2043 (50 μM; 45 min) activates Akt phosporylation via PI3K pathway in A549 cells.
CMX-2043 (2.5 mM; 30 min) diminishes the rise in cytosolic calcium in a concentration-dependent manner in CHO-M1-WT3 cells.

In Vivo: CMX-2043 (50-200 mg/kg, 5 mL; p.o.; single dose) reduces myocardial ischemia-reperfusion injury (IRI) as measured by the myocardial infarct to area at risk (MI-AR) ratio and the incidence of arrhythmia.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Protein Tyrosine Kinase Compound Library  |  Stem Cell Signaling Compound Library  |  Clinical Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Angiogenesis-Related Compound Library  |  Glucose Metabolism Compound Library  |  Peptide Library  |  Antidepressant Compound Library  |  Pain-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Flanvotumab  |  LM22B-10  |  Insulin Detemir  |  (R)-Trolox  |  (rac)-AG-205  |  Ceritinib  |  S961  |  Multi-kinase-IN-2  |  Akt/SKG Substrate Peptide  |  AS1949490  |  Tyrosinase-IN-5  |  1,3-Dicaffeoylquinic acid  |  XMD16-5  |  Threo-Chloramphenicol-d₆  |  AKT-IN-14  |  NSC45586  |  APN/AKT-IN-1  |  MS5033  |  Sophocarpine monohydrate  |  2-Hydroxy-4-methoxybenzaldehyde  |  MS143  |  ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid  |  Deferoxamine  |  Chaetominine  |  Mulberroside A  |  Hu7691 free base  |  AKT-IN-3  |  8-Aminoadenosine  |  2-Ketoglutaric acid  |  Isolindleyin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。