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CAS No. : 1616-93-9
MCE 国际站:β-Amyrin acetate
产品活性:β-Amyrin acetate 是一种三萜类化合物 (triterpenoid),具有有效的抗炎、抗真菌、抗糖尿病、抗高血脂活性。β-Amyrin acetate 可定位在 HMG CoA 还原酶 (HMG CoA reductase) 的 hydrophobic binding cleft,并抑制其活性。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:HMG-CoA Reductase (HMGCR) | Fungal
结构分类:萜类 | 三萜 | 结构分类
来源:植物 | 桑科 | Ficus exasperata Vahl
In Vitro: β-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes.
β-Amyrin acetate (5-100 μM) has HMG-CoA reductase inhibitory activity by locating in the hydrophobic binding cleft lined with residues Leu562, Gly560, Ala564, Gly569, Ser852, Leu853, Leu857, Met854, Ala856, Ser852 and Ala855 of human HMG CoA reductase.
β-Amyrin acetate (7.8-1000 μg/mL, 48 h) inhibits all of the Candida fungal species tested with MIC values ranging from 30 to 250 μg/mL).
In Vivo: β-Amyrin acetate (applied on the anterior surface of the right ear, 100 μg/ear, a single dose) significantly inhibits xylene-induced ear edema in mice.
β-Amyrin acetate (intraperitoneal injection, 4 mg/100 g, daily for 6 consecutive days) shows significant anti-inflammatory activities (43.6%) in adult albino rats.
β-Amyrin acetate (subcutaneous injection, 4 mg/100 g, daily for 10 days ) increases the ATP-phosphohydrolase activity in liver homogenates both in normal and arthritic rats.
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