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CAS No. : 638-97-1
MCE 国际站:β-Amyrone
产品活性:β-Amyrone (β-Amyron) 是一种三萜类化合物,通过抑制 COX-2 的表达而发挥抗炎活性。β-Amyrone 具有抗真菌活性,及针对 Chikungunya 病毒的抗病毒活性。β-Amyrone 还可抑制 α-葡萄糖苷酶 (α-glucosidase ) 和乙酰胆碱酯酶 (AChE) 的活性。β-Amyrone 可用于炎症,感染,肥胖等疾病的研究。
研究领域:Anti-infection | Immunology/Inflammation | Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor
作用靶点:Fungal | COX | PPAR
结构分类:萜类 | 三萜 | 结构分类
来源:植物 | 忍冬科 | 血满草
In Vitro: β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO∙ production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability.
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells.
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM.
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively.
In Vivo: β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice.
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