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Palmatine hydroxide

CAS No. : 131-04-4

MCE 国际站：Palmatine hydroxide

产品活性：Palmatine hydroxide 是一种具有口服活性的、不可逆的 IDO-1 抑制剂，对 HEK 293-hIDO-1 和 rhIDO-1 的 IC₅₀ 分别为 3 μM 和 157 μM。Palmatine hydroxide 也能非竞争性抑制西尼罗病毒 (WNV) NS2B-NS3 蛋白酶，IC₅₀ 为 96 μM。Palmatine hydroxide 具有抗癌、抗炎、神经保护、抗细菌、抗病毒活性。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection  |  Epigenetics  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Indoleamine 2,3-Dioxygenase (IDO)  |  Virus Protease  |  Aurora Kinase  |  Apoptosis  |  Bacterial  |  Parasite

结构分类：生物碱

来源：植物  |  芸香科  |  黄柏

In Vitro: Palmatine (0-100 μM; 42 h) suppresses WNV with an EC₅₀ value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC₅₀ values of 26.4 μM and 7.3 μM, respectively.
Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.
Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway.

In Vivo: Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells.
Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice.
Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.
Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.

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