MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 4643-58-7
MCE 国际站:Verrucarin J
产品活性:Verrucarin J (Muconomycin B) 是 Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis),例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗 Candida albicans 和 Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量,IC50 为 1.2 ng/mL。
研究领域:Apoptosis | Anti-infection | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Apoptosis | Arenavirus | Fungal | Antibiotic | Reactive Oxygen Species
结构分类:其他类
In Vitro: Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC50 values of approximately 10 nM and 20 nM after 48 h of treatment, respectively.
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC50 of 300 nM for HCT 116 and SW-620 cell proliferation.
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells.
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei.
Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe.
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC50) of 8.2 ng/mL.
In Vivo: Verrucarin J (0.5 mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis.
相关产品:SY-5609 | Antifungal agent 26 | D-α-Hydroxyglutaric acid disodium | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Doxorubicin-13C,d3 TFA | PC945 | Antibiotic A-33853 | AAPK-25 | Sulbactam-d2 sodium | Dutasteride-13C6 | Oleic acid-13C | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Chitin synthase inhibitor 11 | Abacavir sulfate | Meloxicam-d3-1 | 7-Hydroxy-4-methyl-2(1H)-quinolone | Thailanstatin D | SB-218078 | Toyocamycin | Sorafenib-d4 | Hispolon | ST-193 hydrochloride | Busulfan | PTC-028 | Trifloxystrobin-d3 | SPR206 acetate
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。