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Sangivamycin

CAS No. : 18417-89-5

MCE 国际站：Sangivamycin

产品活性：Sangivamycin (NSC 65346) 是一种核苷类似物，是蛋白激酶C (PKC) 的有效抑制剂，K_i 为 10 μM。Sangivamycin 对多种人类癌症具有有效的抗增殖活性。

研究领域：Epigenetics  |  TGF-beta/Smad  |  Cell Cycle/DNA Damage

作用靶点：PKC  |  Nucleoside Antimetabolite/Analog

结构分类：其他类  |  结构分类

In Vitro: Sangivamycin has differential antitumor effects in drug-sensitive MCF7/wild type (WT) cells, causing growth arrest, and in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, causing massive apoptotic cell death.
Sangivamycin (0.3 μM; 0-72 hours), shows almost maximal cytocidal (for MCF7/ADR) or cytostatic (for MCF7/WT) effects.
Sangivamycin activates caspases in MCF7/ADR cells. Upon exposure of MCF7/ADR cells to Sangivamycin (0.3 μM;), a vast amount of cleavage of lamin A to a 28-kDa fragment is detected within 48 hours.

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