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Dehydrocorydaline (hydroxyl)

CAS No. :

MCE 国际站：Dehydrocorydaline (hydroxyl)

产品活性：Dehydrocorydaline hydroxyl (13-Methylpalmatine) 是一种生物碱。Dehydrocorydaline hydroxyl 调节 Bax，Bcl-2 蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。Dehydrocorydaline hydroxyl 能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。Dehydrocorydaline hydroxyl 具有强大的抗疟疾作用，并具低细胞毒性 (细胞生存力> 90％)， P. falciparum 3D7 strain (IC₅₀=38 nM)。

研究领域：Apoptosis  |  Epigenetics  |  Cell Cycle/DNA Damage  |  MAPK/ERK Pathway  |  Anti-infection  |  Autophagy

作用靶点：Bcl-2 Family  |  Caspase  |  PARP  |  p38 MAPK  |  Parasite  |  Autophagy

结构分类：生物碱  |  结构分类

来源：植物  |  罂粟科  |  延胡索

In Vitro: Dehydrocorydaline hydroxyl (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline hydroxyl.
Dehydrocorydaline hydroxyl (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
Dehydrocorydaline hydroxyl (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9.

In Vivo: Dehydrocorydaline hydroxyl manifests a low acute toxicity with an LD₅₀ of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection.

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