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Acetyl Gastric Inhibitory Peptide (human) (TFA)

CAS No. :

MCE 国际站：Acetyl Gastric Inhibitory Peptide (human) (TFA)

产品活性：Acetyl Gastric Inhibitory Peptide (human) TFA 是葡萄糖依赖性的胰岛素性多肽的脂肪酸衍生类似物，具有改善的抗高血糖和胰岛素性。Acetyl Gastric Inhibitory Peptide (human) TFA 可用于糖尿病、胰岛素抵抗和肥胖的研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Insulin Receptor

In Vitro: Acetyl Gastric Inhibitory Peptide (human) TFA induces cyclic adenosine 3'5' monophosphate (cAMP) production with an EC₅₀ value of 1.9 nM in Chinese hamster lung fibroblast cells transfected with the human GIP receptor.
Acetyl Gastric Inhibitory Peptide (human) TFA (10^-13-10^-8 nM) shows potent effect at stimulating insulin release compared to the native GIP in BRIN-BD11 cells.
Acetyl Gastric Inhibitory Peptide (human) TFA improves glucose intolerance, type 2 diabetes, beta-cell glucose insensitivity, insulin resistance and reduced insulin secretion.
Acetyl Gastric Inhibitory Peptide (human) TFA has metabolic stability and hypoglycemic and insulin modulating activities of two fatty acid derivatized N-terminally acetylated GIP analogs were evaluated in in vitro and in vivo.

In Vivo: Acetyl Gastric Inhibitory Peptide (human) TFA (25 nmol/kg; i.p.; single dose) shows resistance to plasma dipeptidylpeptidase IV degradation, resulting in enhanced biological activity and improved antidiabetic potential in vivo.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Aging Compound Library  |  Anti-diabetic Compound Library  |  Endocrinology Compound Library  |  Peptide Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Ceritinib  |  S961  |  Kaempferitrin  |  (Pro3) GIP, human  |  KU14R  |  OI338  |  MSDC 0160  |  GIP, human  |  GSK1838705A  |  Demethylasterriquinone B1  |  AG1024  |  Rhoifolin  |  Insulin degludec  |  Insulin (human)  |  AVJ16  |  GIP (1-30) amide,human acetate  |  GIP (3-42), human  |  Gastric Inhibitory Polypeptide (1-30), porcine  |  ERK Inhibitor II (Negative control)  |  Insulin aspart  |  Insulin peglispro  |  BMS-754807  |  GSK1904529A  |  NVP-ADW742  |  BMS-536924  |  Insulin glargine  |  GIP (1-30) amide, porcine TFA  |  NVP-TAE 226

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