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CAS No. : 546-62-3
MCE 国际站:Verbascose
产品活性:Verbascose 是一种低聚乳酸 (GOS),具有强大的免疫刺激活性。Verbascose 可以作为一种潜在的天然免疫调节剂。
研究领域:Others
作用靶点:Others
结构分类:糖类
来源:植物 | 远志科 | 小扁豆
In Vitro: Verbascose (25, 50, 100, 200, 400 μg/mL; 12, 24, 36, 48 hours) significantly increases the viability of RAW264.7 cells.
Verbascose has notable activity of promoting peritoneal macrophages to devour neutral red in a dose-dependent manner and exhibits its maximum activity of cell phagocytosis at a concentration of 200 μg/mL.
Verbascose induces significant increases of NO production. Verbascose can enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleukin (IL)-6, IL-1β, interferon (IFN)-α, and IFN-γ.
In Vivo: Verbascose (30, 90, 120 mg/kg/day; sc; for 8 days) at a medium dose of 90 mg/kg body weight can significantly increase the index of spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity (DTH) of immunosuppressed female Kunming mice.
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