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MCE 国际站:ALK-7 Protein, Rhesus Macaque (HEK293, Fc)
ALK-7 是一种 I 型受体丝氨酸-苏氨酸激酶,通过与 TGF-β 超家族成员结合,介导生长和分化的抑制和刺激信号。ALK-7与特定配体如Nodal、激活素B和生长分化因子(GDF) 结合,可以激活 Smads 等信号通路,从而调节各种细胞的增殖、分化和凋亡。ALK-7 Protein, Rhesus Macaque (HEK293, Fc) 在 HEK293 细胞中产生,由 89 个氨基酸(G25-E113) 组成,在 C 末端带有 Fc 标签。
Synonyms: Activin receptor type IC; ACTR-IC; ACVRLK7; ALK7
Species: Rhesus Macaque
Source: HEK293
研究背景:ALK-7, also known as ACVR1C, is a serine/threonine kinase consistent with the characteristics of a type-I receptor. ALK-7 is predominantly expressed in central nervous system. ALK-7 can form complexes with type II receptor serine-threonine kinases for TGF-β and activin in a ligand-dependent manner.
The ALK-7 gene encodes a 55-kDa cell-surface protein that exhibits up to 78% amino acid sequence identity in the kinase domain to previously isolated type I receptors for TGF-β and activin. In the extracellular domain, however, ALK-7 is more divergent, displaying comparable similarities with all members of the ALK subfamily. Originally identified and cloned from rat brain, ALK-7 mRNA is present throughout the digestive and central nervous system of rats. The function of ALK-7 as a type I receptor was confirmed with a constitutively activemutant form that activated a TGF-β/activin response reporter. ALK-7 has also been found to activate some components of the Smad pathway, such as Smad2 and Smad3, in fetal and adult rat pancreas. In the rat pheochromocytoma PC12 cell line, ALK-7 not only activated both Smad2, Smad3, and the MAPK of extracellular signal-regulated kinase and JNK, but it inhibits cell proliferation as well. The human gene for ALK-7 has been mapped to the genetic location of 2q24.1-q3, with most of the mRNA located in the brain, pancreas, and colon. ALK-7 mediates high-ambient glucose-induced cardiomyoblasts apoptosis through the activation of Smad2/3.
ALK-7 combined with specific ligands, such as Nodal, activin B and growth differentiation factor (GDF), can activate Smads and other signaling pathways, thereby regulating cell proliferation, differentiation and apoptosis in various cells. Besides that, ALK-7, along with ALK-5 and ALK-6, participated in renal interstitial fibrosis.
蛋白编号:F7GDQ6 (G25-E113)
基因 ID:697826
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 活化素受体样激酶 7 | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 活化素受体样激酶 7 | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 活化素受体样激酶 7
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | ALK-7 | Receptor Proteins | Receptor Serine/Threonine Kinases | ALK-7 | Enzymes & Regulators | Serine/Threonine Kinase Proteins | ALK-7
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