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CAS No. : 25541-09-7
MCE 国际站:Lacto-N-fucopentaose III
产品活性:Lacto-N-fucopentaose III (LNFP-III) 是一种免疫调节剂。Lacto-N-fucopentaose III 可降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度。
研究领域:Immunology/Inflammation | Metabolic Enzyme/Protease
作用靶点:Arginase | Aldehyde Dehydrogenase (ALDH) | Indoleamine 2,3-Dioxygenase (IDO)
结构分类:糖类 | 多糖 | 结构分类
In Vitro: Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) induces the production of nitric oxide in inflammatory monocytes. Lacto-N-fucopentaose III reduces migration of dendritic cells across brain endothelium.
Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) significantly increased mRNA expression of arginase I (Arg1), aldehyde dehydrogenase 1, subfamily A2 (Aldh1a2), indoleamine 2,3-dioxygenase 1 (Ido1), and heme oxygenase 1 (Homx1).
In Vivo: Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation, and skews peripheral immune response to a Th2 dominant profile in mice.
Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model.
相关产品:Alda-1 | IDO1/2-IN-1 hydrochloride | CAY10581 | Coptisine chloride | Broussonin E | Indoximod | IDO-IN-18 | 4-Hydroxynonenal | IDO1-IN-20 | Nitrefazole | ZC0101 | 4-Diethylaminobenzaldehyde | Numidargistat dihydrochloride | RV01 | ALDH1A2-IN-1 | Arginase inhibitor 1 | IDO/TDO-IN-1 | IDO1-IN-21 | nor-NOHA acetate | IDO-IN-16 | IDO1/TDO-IN-1 | IGUANA-1 free base | IDO5L | IDO-IN-8 | NCT-501 | GNF-PF-3777 | Disulfiram | BEC hydrochloride | BMT-297376
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