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Fas Ligand Protein, Human (P.pastoris, His)

MCE 国际站：Fas Ligand Protein, Human (P.pastoris, His)

Fas Ligand (CD178;APTL) 是 TNFRSF6/FAS/CD95 的配体，转导凋亡信号以调节细胞毒性 T 细胞介导的凋亡，自然杀伤细胞介导的凋亡和 T 细胞发育。人源 Fas Ligand 具有 4 种亚型，其中可溶形式 (130-281 a.a.) 在 T 淋巴 Jurkat 细胞的活化诱导细胞死亡 (AICD) 中起重要作用。而 Fas Ligand 的膜结合亚型则负责其炎症活性。重组人 Fas 配体 (P.pastoris, His) 全长 148 个氨基酸 (P134-L281)，包含一个 TNF_2 结构域 (146-281 a.a.)。该蛋白由 P.pastoris 细胞表达，带有 N 端 His 标签。

Synonyms: Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6

Species: Human

Source: P. pastoris

研究背景：Fas Ligand (FasL; FASLG; CD95L), is a ligand for TNFRSF6/FAS belonging to the tumor necrosis factor (TNF). FasL is a type II transmembrane protein, riggering apoptosis of lymphocytes.
FasL is expressed on a variety of cell types, including T cells, natural killer (NK) cells, monocytes, neutrophils, breast epithelial cells, and vascular endothelial cells.
FasL exerts different biological activity by cleaved into 4 isoforms including membrane form, soluble form, ADAM10-processed FasL form (APL) and SPPL2A-processed FasL form (SPA). Among them, the membrane-bound form and a soluble form generated by proteolytic action of matrix metalloproteinases (MMP).
FasL or soluble FasL binding to Fas results in receptor aggregation and in the interaction of a protein called Fas-associated death domain with the Fas cytoplasmic tail. The interaction triggers a cascade of intracellular events, including the activation of the IL-1-converting enzyme-like cysteine protease (caspase 8), that ultimately leads to nucleoprotein cleavage, DNA fragmentation, and cell apoptosis.
The loss of function due to mutations in murine FasL, murine Fas, human Fas, or human FasL leads to lymphoproliferation, lymphadenopathy, and autoimmune diseases.
Meanwhile, defective activation-induced cell death (AICD) results in spontaneous mutation of Fas and FasL genes in mice with lupus-like autoimmune disease.
Human Fas Ligand also involves in Jurkat cell apoptosis and binds TNFRSF6B/DcR3 to bolck apoptosis, which is a decoy receptor of apoptosis termination.
FasL is widely found in different animals, while the sequence in Human is different from Rat and Mouse with similarity of 77.26% and 78.06%, respectively.

蛋白编号：Q53ZZ1 (P134-L281)

基因 ID：356

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  Fas 配体  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  上皮细胞 CD 蛋白  |  CD178/FasL  |  CD 抗原  |  内皮细胞 CD 蛋白  |  CD178/FasL

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  Fas Ligand (FasL)  |  CD Antigens  |  T Cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  NK Cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  Epithelial cell CD Proteins  |  CD178/FasL  |  CD Antigens  |  Endothelial cell CD Proteins  |  CD178/FasL

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