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IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc)

MCE 国际站：IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc)

IFN-alpha 4 (IFNA4) 属于 I 型干扰素家族，由巨噬细胞产生而具有抗病毒活性。重组大鼠 IFN-alpha 4/IFNA4 蛋白 (HEK293, Fc) 含有 166 个氨基酸 (C24-K189)，由 HEK293 细胞产生并带有 N 端 hFc 标签。

Synonyms: Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76

Species: Rat

Source: HEK293

研究背景：IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs).
IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus.
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA4 protein of rat shows 80.98% similarity with mouse, but is very different from human (57.98%).

蛋白编号：D3ZFH0 (C24-K189)

基因 ID：298205

产品分类：细胞因子和生长因子  |  干扰素  |  干扰素 α  |  干扰素 α4

Categories：Cytokines and Growth Factors  |  Interferon & Receptors  |  IFN-alpha  |  IFN-alpha 4

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