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IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi)

MCE 国际站：IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi)

IL-23 alpha 和IL-12 beta 分别是 IL-23p19 和 IL-12p40 亚基，通过异二聚的方式组成 IL-23。IL-23 与由 IL-12RB1 和 IL-23R 组成的异二聚受体结合，激活 Jak-Stat 信号级联，并优先作用于记忆 CD4(+) T 细胞。IL-23 还参与多个通路的激活，包括 p38 MAPK 或 NF-κB，并促进促炎细胞因子如白细胞介素 IL-17A 的产生。重组人 IL-23 alpha (170a.a) & IL-12 beta (306a.a) 异二聚体蛋白在 HEK293 细胞中产生，全长 476 个氨基酸，带有 C 端 His-avi 标签。

Synonyms: IL23 alpha; IL12 beta; IL23 alpha&IL12 beta

Species: Human

Source: HEK293

Biological Activity: Immobilized Human IL-23 alpha&IL-12 beta, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-IL-23 Antibody, hFc Tag with the EC₅₀ of 6.0ng/ml determined by ELISA.

研究背景：IL-23 alpha and IL-12 beta, also known as IL23p19 and IL12p40, respectively, and composing IL-23 in a heterodimerization manner, exerts proinflammatory effects and promotes angiogenesis.
IL-23 belongs to the IL-12 cytokine family together with IL-12 p35/p40, IL-27 EBI3/p28 and IL-35 EBI3/p35, and is produced by various immune cells such as dendritic cells and macrophages upon Toll-like receptor signaling in tissues.
IL-23 has a preference expression on memory CD4(+) T cells, and activates the Jak-Stat signaling cascade. IL-23 leads to IL-23 receptor phosphorylation and forms a docking site to trigger phosphorylation signal of STAT3 and STAT4.
IL-23 is a key factor perpetuating Th17 cell activation and cytokine production by binding IL-23 receptor to produce Th17 cytokines such as IL17 A, IL-17 F and IL-22.
IL-23 also acts function on natural killer cells, results interferon-γ secretion increasing and enhances antibody-dependent cellular cytotoxicity.
The sequence of amino acids in IL-23 alpha proteins of human shows high similarity with Cynomolgus (97.88%) and is very different from mouse (74.60%) or rat (79.37%), while the sequence of IL-12 beta proteins of human is very different from mouse (69.04%) and rat (69.04%).
IL-23 facilitates development of inflammation in numerous other models of immune pathology where IL-12 had previously been implicated, including models of arthritis,intestinal inflammation, and psoriasis.

蛋白编号：Q9NPF7 (R20-P189)&P29460 (I23-S328)

基因 ID：51561&3593

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-12  |  白介素-12B  |  细胞因子和生长因子  |  白细胞介素  |  白细胞介素-23  |  生物素标记蛋白

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-12  |  IL-12 beta  |  Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-23  |  Biotinylated Proteins

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