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MCE 国际站:ACSS1 Protein, Human (P.pastoris, His)
ACSS1 Protein, Human (P.pastoris, His) 是一种线粒体基质酶,在心脏、骨骼肌和棕色脂肪组织中表达。ACSS1 Protein, Human 参与醋酸盐介导的表观遗传调控。
Synonyms: ACAS2L; Acetate CoA ligase 2; Acetate--CoA ligase 2
Species: Human
Source: P. pastoris
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:Acyl-CoA short-chain synthetases (ACSS1, ACSS2, ACSS3) are the only known mammalian enzymes that can convert free acetate into acetyl-CoA. ACSS1 and ACSS2 predominantly utilize acetate as substrate, whereas ACSS3 preferentially uses propionate. The activity of these enzymes is regulated, in part, by acetylation and deacetylation of specific lysine sites. Acetylation inactivates both ACSS1 and ACSS2, whereas deacetylation reactivates them. ACSS1 is a mitochondrial matrix enzyme that is strongly expressed in heart, skeletal muscle and brown adipose tissue. This isoform primarily generates acetyl-CoA that will enter the citric acid cycle for energy derivation via oxidation to CO2.
蛋白编号:Q9NUB1 (38A-689K)
基因 ID:84532
产品分类:酶和调节子 | 裂解酶
Categories:Enzymes & Regulators | Lyases (EC 4)
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