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MCE 国际站:AICDA Protein, Mouse (His-Myc)
AICDA Protein, Mouse (His-Myc) 是一种介导亲和力成熟并促进生发中心 B 细胞 DNA 去甲基化的酶。AICDA Protein 过表达会导致 BCL2 驱动的小鼠淋巴瘤更具侵袭性。
Synonyms: Aicda; Aid; Single-stranded DNA cytosine deaminase; EC 3.5.4.38; Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase
Species: Mouse
Source: E. coli
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:Activation-induced cytidine deaminase (AICDA), an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells, is required for DLBCL pathogenesis and linked to inferior outcome. AICDA overexpression causes more aggressive disease in BCL2-driven murine lymphomas. Besides the role of AICDA in modifying cytosine methylation during the GC reaction13, AICDA is additionally a critical source of epigenetic heterogeneity in DLBCL. AICDA-linked epigenetic heterogeneity is predominantly associated with relative loss of cytosine methylation, consistent with the known mechanism of action of AICDA in cytosine deamination. AICDA-induced epigenetic heterogeneity increases plasticity, permitting cancer cells a greater degree of population diversity and enhancing the adaptive capacity of the overall tumor.
蛋白编号:Q9WVE0 (M1-F198)
基因 ID:191
产品分类:酶和调节子 | 水解酶
Categories:Enzymes & Regulators | Hydrolases (EC 3)
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