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MCE 国际站:IL-6R Protein, Rat (HEK293, Fc)
IL-6R alpha 是 IL-6R 的 α 亚基,也被其他白细胞介素受体共享。IL-6R alpha 作为 IL-6 激动剂,参与包括 JAK/STAT、MAPK 和 Akt 在内的信号通路。IL-6R alpha, Rat 由 462 个氨基酸 (M1-R462) 组成,存在 1 个 N 端纤维连接蛋白 III 型结构域 (215-313 a.a) 和跨膜结构 (365-385 a.a)。可溶性 IL-6R (sIL-6R) 与 SORL1 相互作用以发生内化,并结合 IL-6 和二聚体 gp130 传递反式信号。IL-6R alpha, Rat (I44-E357) 在 HEK293 细胞中产生,是可溶 IL-6R alpha 片段,并带有 C- 末端 hFc 标记。
Synonyms: Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126
Species: Rat
Source: HEK293
研究背景:IL-6 acts as both inflammatory factor and anti-inflammatory factor, fuels cancer progression through activating a series of downstream signalling cascade including gp130 (dimers), JAK/STAT, MAPK, and Akt.
IL-6R alpha (IL-6Rα) as a part of the receptor for interleukin 6, is a type I transmembrane glycoprotein, which forms a complex with the type I transmembrane signal transducer Glycoprotein 130 (CD130) and regulates the biological activity of IL-6 with a low affinity.
The sequence of amino acids in IL-6R alpha proteins of rat is very different from human (54.68%), but shows high similarity with mouse (89.3%).
IL-6R alpha has 2 isoform including mIL6R (the longer one) or sIL6R (the shorter one):
The mIL6R is membrane-bound interleukin-6 receptor, has the potential to drive naive CD4+ T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells.
The sIL-6R is soluble interleukin-6 receptor subunit, cleaved from IL-6R alpha (IL-6Rα) in activated CD4+ T cells by proteolysis, and serves as IL-6 agonist. sIL-6R binds membrane-bound IL6R and subunit IL6ST to activate regenerative and anti-inflammatory signal via IL-6 trans signaling and promotes pro-inflammatory properties of IL-6. The hydrolysis of IL-6R alpha is also called ectodomain shedding.
IL-6R alpha involves in regulating cell growth and differentiation, and plays an important role in regulation of immune response, acute-phase reactions and hematopoiesis.
However, IL-6R alpha shows tissue expression specificity in liver and some cells of the immune system, thus results a limitation of IL6 signaling.
It's worth noting that IL-6R alpha dysregulation is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer.
蛋白编号:P22273 (M1-P364)
基因 ID:24499
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-6 受体 | 白细胞介素-6 受体 alpha | CD 抗原 | T 细胞 CD 蛋白 | IL-6R/CD126 | CD 抗原 | 巨噬细胞 CD 蛋白 | IL-6R/CD126 | CD 抗原 | 干细胞 CD 蛋白 | IL-6R/CD126 | CD 抗原 | 上皮细胞 CD 蛋白 | IL-6R/CD126
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-6R | IL-6R alpha | CD Antigens | T Cell CD Proteins | IL-6R/CD126 | CD Antigens | Macrophage CD Proteins | IL-6R/CD126 | CD Antigens | Stem Cell CD Proteins | IL-6R/CD126 | CD Antigens | Epithelial cell CD Proteins | IL-6R/CD126
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