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MCE 国际站:AITRL/TNFSF18 Protein, Mouse
AITRL,一种 II 型跨膜蛋白,是糖皮质激素诱导的 TNFR 相关蛋白 (GITR) 的配体。当 AITRL 与 GITR 结合时,GITR 可以产生调节 T 细胞增殖和效应子功能的共刺激信号。GITR/GITRL 相互作用在肿瘤、炎症以及自身免疫性疾病的发病中发挥着重要作用。此外,AITRL 还在内皮细胞 (ECs) 的激活中发挥作用,并促进小鼠和人类细胞的粘附,从而增加 STAT-1 磷酸化和粘附分子 (如 VCAM-1 和 ICAM-1) 的表达。AITRL/TNFSF18 Protein, Mouse 是一种重组小鼠 AITRL (T47-S173),不带标签,在 E.coli 中表达。
Synonyms: rMuActivation-inducible TNF-related Ligand/AITRL; TNFSF18; GITRL; TL-6
Species: Mouse
Source: E. coli
Biological Activity: The ED50 is <5 ng/mL as measured by PMBC, corresponding to a specific activity of >2 × 105 units/mg.
研究背景:GITRL (AITRL), a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). GITR, a member of the TNFR superfamily, is expressed in T cells, natural killer cells and some myeloid cells. And murine GITRL has been detected on dendritic cells (DCs), monocytes, macrophages, B cells, endothelial cells, osteoclasts, and microglia cells.
When GITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. The interaction stimulates proliferation and cytokine production of both CD4+ Teff and Treg cells, and drives antitumor activity of CD8+ T cells. Besides, GITRL plays a role in EC-activation and promotes adhesion in both mice and humans, which increases STAT-1 phosphorylation and the augmented expression of adhesion molecules such as VCAM-1 and ICAM-1. Mouse GITRL can activate signal transduction, including inducing a tolerogenic effect in DCs and pro-inflammatory stimuli in macrophages.
Mouse GITRL shares < 55% common aa identity with human. Murine GITRL exists as a dimerGITR/GITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases
蛋白编号:Q7TS55 (T47-S173)
基因 ID:240873
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | 糖皮质激素诱导的 TNF 受体配体
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | GITRL/AITRL
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