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TNF-beta/TNFSF1 Protein, Human

MCE 国际站：TNF-beta/TNFSF1 Protein, Human

TNF-β (tumor necrosis factor β) 又称淋巴毒素-α (LT-α)，是肿瘤坏死因子超家族的成员，是一种由淋巴细胞产生的细胞因子。TNF-β 激活 NF-κB 信号通路，诱导癌细胞增殖、侵袭。TNF-β 上调转移相关基因的表达，促进上皮-间质转化，刺激自身表达。TNF-β 介导多种炎症、免疫刺激和抗病毒反应。TNF-beta/TNFSF1 Protein, Human 是一种由大肠杆菌表达的重组蛋白，由 171 个 (L35-L205) 氨基酸组成。

Synonyms: rHuTNF-β; TNF-β; TNFSF1; Lymphotoxin-alpha

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <80 pg/mL as measured by L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of >1.25 × 10⁷ units/mg.

研究背景：TNF-β is expressed by a variety of cells, including T cells, B cells and natural killer (NK) cells.
The amino acid sequence of human TNF beta protein has low homology between mouse and rat TNF alpha protein. While, rat TNF alpha shares 95.54% aa sequence identity with mouse TNF alpha protein.
TNF-β can be secreted and binds with high affinity to TNF receptors 1 and 2 (TNFR-1 and TNFR-2), and it is transiently expressed on the cell surfaces of activated B and T cells, where it forms a complex with LT-β as an LTα1β2 heterotrimer, activates NF-kB, MAPK, and PI3K/AKT pathways and induces cancer cells proliferation, invasion.
TNF-β is translated as a 25 kDa glycosylated polypeptide with 171 amino acid residues. TNF-β up-regulates of NF-κB signaling and activates of pro-inflammatory activity.TNF-β induces tumor cells proliferation, migration and increases the expression of p-p65, p-IkBα in a dose dependent manner.

蛋白编号：P01374 (L35-L205)

基因 ID：4049

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  肿瘤坏死因子-β

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  TNF-β

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