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MCE 国际站:RANK/TNFRSF11A Protein, Rat (HEK293, Fc)
RANK 是核因子 κB (NF-κB) 的受体激活因子,参与骨代谢和免疫系统功能。RANK 主要由成骨细胞/基质细胞表达,与骨巨细胞瘤 (GCTBs) 形成相关。RANK 结合RANKL 配体,启动 RANKL/RANK/骨保护素 (OPG) 系统调节骨吸收。RANKL/RANK 还是树突状细胞 (DC)-T细胞的相互作用的调节因子,与哺乳女性乳腺上皮的形成和中枢神经系统的体温调节相关。 重组大鼠 RANK/TNFRSF11A 蛋白 (HEK293, Fc) 全长 213 个氨基酸 (M1-P213),由 HEK293 细胞表达,带有 C 端 hFc 标签。
Synonyms: Tumor necrosis factor receptor superfamily member 11A; ODFR; CD265
Species: Rat
Source: HEK293
研究背景:RANK (TNFRSF11A), is the receptor activator of nuclear factor-κB (NF-κB), has originally been described to play key roles in bone metabolism and the immune system. RANK belongs to tumor necrosis factor receptor superfamily, acts function during osteoclasts differentiation and activation. RANK expressed by osteoblast/stromal cells, ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. However, osteoblast typically are present in large numbers in giant cell tumors of bone (GCTBs), suggesting the affect of expressing factors in tumors that stimulate osteoclasts precursor recruitment and differentiation. RANK binds RANKL, the receptor activator of NF-κB ligand, to trigger RANKL/RANK/osteoprotegerin (OPG) system to regulate bone resorption. Specifically, the RANKL/RANK signaling pathway promotes the formation of multicellular osteoclast precursors and ensures the activation and survival of multicellular osteoclasts under normal bone remodeling and various pathological conditions. OPG protects bone from excessive bone resorption by competitively binding to RANKL and hindering RANK binding to RANKL. In addition to RANK's contribution to bone metabolism, the RANKL/RANK system is also involved in dendritic cell (DC)-T cell interactions. In rheumatoid synovium and lymph node pairs, the expression levels of RANK and RANKL can be used as markers to determine the interaction between dendritic cells and T cells. Moreover, RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. As them under the tight control of the female sex hormones estradiol and progesterone, RANKL-RANK causes osteoporosis in postmenopausal women when circulating female sex hormones decrease. Furthermore, RANKL-RANK signaling also plays a critical role in other bone pathologies, bone metastasis or hormone-driven breast cancer.
蛋白编号:F1M8Z6 (M1-P213)
基因 ID:498206
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | 核因子-κB 受体激活因子 | CD 抗原 | 巨噬细胞 CD 蛋白 | RANK/CD265
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | RANK Proteins | CD Antigens | Macrophage CD Proteins | RANK/CD265
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