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MCE 国际站:AGR3 Protein, Mouse (HEK293, His)
AGR3 Protein, Mouse (HEK293, His)是在 C 末端带有 His 标签的小鼠重组 Agr3,由哺乳动物表达系统产生,并表达编码 Ile21-Leu165 的靶基因。
Synonyms: rMuAgr3, His; Agr3; Anterior gradient protein 3
Species: Mouse
Source: HEK293
研究背景:Anterior gradient protein 3 (AGR3) is a homologue of the pro-oncogenic AGR2. AGR3 and AGR2 share a 71% sequence identity and lie adjacent to one another at chromosomal position 7p2. Functionally, they belong to the protein disulfide isomerases (PDIs) family, which act as endoplasmic reticulum (ER)-resident molecular foldases involved in the maintenance of cellular homeostasis. AGR3 is an ER resident protein, which is required for the regulation of ciliary beat frequency and mucociliary clearance in the airway epithelium. AGR3 was shown to interact with dystroglycan-1 (DAG-1) and metastasis-associated C4.4A protein, indicating its potential as a driver of metastasis. AGR3 is a potential promising target for anti-tumor therapy. Elevated AGR3 expression levels were reported in some cancer types, including breast, liver, prostate and ovary.
蛋白编号:Q8R3W7 (I21-L165)
基因 ID:403205
产品分类:其他
Categories:Others
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