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MCE 国际站:IFN-alpha 5/IFNA5 Protein, Mouse (P.pastoris, His)
IFN-alpha 5 (IFNA5) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组小鼠 IFN-alpha 5/IFNA5 蛋白 (P.pastoris, His) 含有 168 个氨基酸 (C24-E189),由 P. pastoris 酵母细胞产生并带有 C 端 His 标签。
Synonyms: Interferon alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G
Species: Mouse
Source: P. pastoris
研究背景:IFN-alpha 5 (IFNA5; IFN-α5), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFN-alpha 5 involves in innate immunity, and is one of the genes associated with acute viral bronchiolitis (AVB) caused by respiratory syncytial virus (RSV), determining susceptibility to RSV bronchiolitis.
The excessively expressed interferon-α (IFN-α) might contribute to the uncontrolled inflammatory responses, causing pathological damage during influenza virus infection. However IFN-alpha 5 is dominantly expressed in respiratory epithelial cells from the patients infected with less pathogenic infectious bronchitis virus (IBV).
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA5 protein of mouse is very different from human (60.32%).
蛋白编号:Q810G2 (C24-E189)
基因 ID:15968
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α5
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 5
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