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TL1A/TNFSF15 Protein, Mouse

MCE 国际站：TL1A/TNFSF15 Protein, Mouse

TL1A 蛋白 (VEGI 蛋白)，属于肿瘤坏死因子 (TNF) 家族，是 TNFRSF25 和 TNFRSF6B 的受体。TL1A 参与了 NF-κ-B 和 C-Jun 通路的激活，可作为黏膜免疫的调节剂，参与炎症性肠病 (IBD) 发病的免疫通路。TL1A 来源于内皮细胞，可抑制乳腺癌、上皮和髓系肿瘤细胞的增殖。小鼠 TL1A 蛋白有一个跨膜结构域 (40-60 a.a.)，可被切割成膜型肽片段和可溶性肽片段。重组小鼠 TL1A/TNFSF15 蛋白 是 TL1A 蛋白的胞外部分 (A61-L252)，由 E.coli 大肠杆菌表达，不带标签。

Synonyms: Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI

Species: Mouse

Source: E. coli

研究背景：TL1A (Tumor necrosis factor-like cytokine 1A), also known as TNF ligand-related molecule 1 and vascular endothelial cell growth inhibitor (VEGI), is the receptor for TNFRSF25 and TNFRSF6B, acts as a regulator of mucosal immunity and participates in immunological pathways involved in the inflammatory bowel diseases (IBD) pathogenesis. TL1A belongs to the tumor necrosis factor family, derived from endothelial cell. It is a ligand for DR3 and decoy receptor TR6/DcR3, the interaction with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect. Moreover, DR3 is the death domain-containing receptor, that is upregulated during T cell activation. TL1A shows an inducible expression by TNF and IL-1alpha, and induces NF-kappaB activation and apoptosis in DR3-expressing cell lines. Meanwhile, TL1A acts as a costimulator that increases IL-2 responsiveness and secretion of proinflammatory cytokines. In addition, TL1A activates c-Jun N-terminal kinase. TL1A also activates caspase-3 leading to PARP cleavage, and inhibits the proliferation of breast carcinoma, epithelial, and myeloid tumor cells. TL1A promotes proliferation of normal human fibroblast cells. These results suggest that VEGI, a new member of the TNF family, has a signaling pathway similar to TNF and is most likely a multifunctional cytokine. Mouse TL1A protein has two glycosylated domains and one transmembrane domain (36-56 a.a.), and can be cleaved into membrane-type peptide fragments and soluble peptide fragments. The protein sequence of mouse is much different from rat and human with similarities of 85.32% and 68.42%, respectively.

蛋白编号：AAV33431.1 (I76-L252)

基因 ID：326623

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  TL1A 蛋白

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  TL1A

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