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MCE 国际站:BMPR-II Protein, Human (HEK293, His-Fc)
BMP II 型受体 (BMPR2) 是跨膜丝氨酸/苏氨酸激酶骨形态发生蛋白 (BMP) 受体家族的 II 型成员。BMPR2 在心脏和肝脏中高度表达,参与成骨和细胞分化,对胚胎发生、发育和成体组织稳态至关重要。BMPR2 与微管蛋白的稳态相关,抑制 BMPR2 会破坏微管的稳定,促进癌细胞的细胞死亡,这一过程也涉及到溶酶体的激活。人的 BMPR2 蛋白全长 1038 个氨基酸,含有一个跨膜结构域 (151-171 a.a.)。重组人 BMPR-II 蛋白 (HEK293, His-Fc) 由 HEK293 细胞表达 (M1-I151),是完整 BMPR2 蛋白的胞外部分,带有 C 端 hFc 和 His 标签。
Synonyms: Bone morphogenetic protein receptor type-2; BMPR-2; BMPR-II; PPH1
Species: Human
Source: HEK293
研究背景:BMP Type II Receptor (BMPR2) is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPs are involved in endochondral bone formation and embryogenesis, transducing signals through the formation of heteromeric complexes of 2 types BMP receptors: type I receptors (50-55 kD) and type II receptors (70-80 kD). Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. The BMPR2 pathway inhibits smooth muscle cell (SMC) proliferation within the pulmonary circulation, primarily within the small pulmonary arterioles. When mutated, BMPR2 is associated with an increased susceptibility to develop pulmonary arterial hypertension (PAH). BMPR2 is essential for tubulin stability, as recent studies have shown that BMP2 regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcription factor. Mutations in BMPR2 trafficking proteins leads to overactive BMP signaling, which leads to neurological diseases caused by BMPR2 stabilization of the microtubules. Inhibition of BMPR2 destabilizes the microtubules, thus leads to lysosomes activation in promoting cell death progress of cancer cells. Particularly, there is strong correlation between BMPR2 promoter DNA methylation and the severity of valvular heart disease (VHD), which makes BMPR2 serve as good biomarkers of VHD. Meanwhile, DNA methylation may cause PAH through deregulation of BMP signaling and increased apoptosis. The sequences of BMPR2 protein are conserved among different species, and the sequence of human shares a high similarity with rat (96.15%) and mouse (96.63%), respectively.
蛋白编号:Q13873 (M1-I151)
基因 ID:659
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 骨形态发生蛋白受体 | 骨形态发生蛋白 II 型受体
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | BMP Receptor | BMP Type II Receptor (BMPR2)
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