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MCE 国际站:Fas/CD95 Protein, Human (HEK293, Fc)
Fas 受体是一种细胞表面死亡受体,又称凋亡介导表面抗原 Fas 和 Apo-1 抗原。Fas 受体与 Fas 配体结合而形成死亡诱导信号复合物,如 Fas 相关死亡结构域蛋白 (FADD)。Fas 受体参与 caspase 级联反应,调节下游 JNK 和 p38-K 的激活。它还介入 ERK/JNK MAPKs 信号级联,激活 MAPK3/ERK1, MAPK8/JNK 和 NF-κB,与多种恶性肿瘤和免疫系统疾病的发病机制有关。人 Fas 受体含有一个死亡结构域 (230-314 a.a.),在调节程序性死亡中发挥关键作用。重组人 Fas/CD95 蛋白 (HEK293, Fc) 全长 173 个氨基酸 (M1-N173),由 HEK293 细胞表达,带有 C 端 hFc 标签。
Synonyms: Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; APT1; FAS1; TNFRSF6
Species: Human
Source: HEK293
研究背景:Fas receptor is the receptor for TNFSF6/FASLG, also known as apoptosis-mediating surface antigen FAS and Apo-1 antigen. It is a cell-surface protein that mediates apoptosis upon ligation with Fas ligand. Fas receptor belongs to tumor necrosis factor receptor superfamily, there are 7 isoforms produced by alternative splicing, some of which are candidates for nonsense-mediated mRNA decay (NMD). The Fas gene is expressed in several tissues in human and mouse, including thymus, spleen, ovary and heart, and on a number of cell types, including activated T- and B-lymphocytes. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. Fas receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. It interacts with its ligand to allow the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. To be specific, the autoproteolytic processing of the caspase in the complex triggers a downstream caspase cascade, including activation of the acidic sphingomyelinase, consumption of sphingomyelin, release of ceramide, and subsequent activation of JNK and p38-K. Thus, Fas receptor acts fucntion via caspase’s regulation and leads to apoptosis. Moreover, the signaling initiated from Fas is mediated by mitogen activated protein kinases (MAPKs) including extracellular-signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) which induce subsequent activation of NF-κB. Meanwhile, stimulation of Fas induced the expression of pro-inflammatory mediators such as matrix metalloproteinase (MMP)-9 and IL-8. The amino acid sequence of human Fas protein has low homology with that of rat and mouse, and the similarity rate is 49.54% and 48.93%, respectively.
蛋白编号:P25445 (M1-N173)
基因 ID:355
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | Fas 受体 | CD 抗原 | T 细胞 CD 蛋白 | CD95/Fas | CD 抗原 | B 细胞 CD 蛋白 | CD95/Fas | CD 抗原 | NK 细胞 CD 蛋白 | CD95/Fas
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | Fas Receptor | CD Antigens | T Cell CD Proteins | CD95/Fas | CD Antigens | B Cell CD Proteins | CD95/Fas | CD Antigens | NK Cell CD Proteins | CD95/Fas
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