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MCE 国际站:CD30 Ligand/TNFSF8 Protein, Human (HEK293, Fc)
CD30L 蛋白是 B 细胞表面抗原,是 CD30 (TNFRSF8) 配体,对 CD40 介导的免疫球蛋白类转换起抑制作用。CD30 Ligand 也是霍奇金淋巴瘤和相关血液恶性肿瘤的标记物,参与 T 细胞依赖性免疫系统的激活和功能。CD30L 蛋白在 T 和 B 淋巴细胞、巨噬细胞、各种正常造血细胞和衍生肿瘤中表达。CD30L 蛋白调控着正常和恶性淋巴样细胞的死亡、分化和细胞分裂。而来源人的 CD30L 蛋白是一种 II 型跨膜糖蛋白,属于肿瘤坏死因子 (TNF) 家族。重组人 CD30 Ligand/TNFSF8 蛋白 (HEK293) 全长 172 个氨基酸 (Q63-D234),在 HEK293 细胞中表达,带有 N 端 hFc 标签。
Synonyms: Tumor necrosis factor ligand superfamily member 8; CD153; CD30L; CD30LG
Species: Human
Source: HEK293
研究背景:CD30 Ligand (CD30L) is a B cell surface antigen and a ligand for CD30 (TNFRSF8), playing an inhibitory role in CD40-mediated immunoglobulin class switching.
CD30L is a type II membrane-associated glycoprotein belonging to the tumor necrosis factor (TNF) family, structurally related to tumour necrosis superfamily members TNF alpha, TNF beta, and CD40.
CD30L enhances cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines to play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. CD30L also enhances release of cytokine IL-6, TNF, LT-a.
CD30L exerts pleiotropic effects on normal and malignant lymphoid cells, including death, differentiation, or cell division regulation.
CD30L is mainly expressed on activated T cells, B cells, macrophages and DCs, while CD30/CD30L mainly expressed on the surface of activated CD4+ T cells in the lamina propria (LP), especially at the early stage of Th17 cell differentiation. CD30L deficiency could inhibit Th17 cell differentiation and production of IL-17A in the intestinal mucosa.
CD30L acts as a pro-inflammatory cytokines, is involved in the adaptive immune response in ulcerative colitis (UC), the level of which shows positive correlation with the severity of UC.
蛋白编号:P32971 (Q63-D234)
基因 ID:944
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | CD30L 蛋白 | CD 抗原 | T 细胞 CD 蛋白 | CD153/CD30L | CD 抗原 | 巨噬细胞 CD 蛋白 | CD153/CD30L
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | CD30 Ligand | CD Antigens | T Cell CD Proteins | CD153/CD30L | CD Antigens | Macrophage CD Proteins | CD153/CD30L
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