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MCE 国际站:IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc)
IL-27R α (白细胞介素 27 受体 α) 是白细胞介素 27 受体的一个亚基,IL-27 受体是一种具有广泛免疫功能的炎性细胞因子。IL-27R α 可用作天然的 IL-27 拮抗剂。IL-27R alpha/TCCR Protein, Human (514a.a, HEK293, Fc) 是一种重组蛋白,C 末端带有 Fc 标签,由 514 个氨基酸组成 (M1-R514),在 HEK293 细胞中表达。
Synonyms: Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA
Species: Human
Source: HEK293
研究背景:IL-27Rα is specific for IL-27 and is primarily expressed on the cell surface of inflammatory cells, including T, B, and NK lymphocytes, neutrophils, monocytes, and mast cells, although it is found at lower levels in macrophages, hepatocytes, keratinocytes, and endothelial cells.
The amino acid sequence of human IL-27R alpha protein has low homology for mouse IL-27R alpha protein.
IL-27Rα (WSX-1) and gp130 compose the IL-27 receptor-signaling complex. Binding of IL-27 to its heterodimeric receptor complex leads to the intracellular recruitment and activation of the Janus kinase (JAK)/STAT-1 and STAT-3 pathways, suppress the expression of inflammatory cytokines.
IL-27R alpha is a class I cytokine receptor with homology to gp130 of IL-6R and to IL-12R families. IL-27R alpha can be used as a natural IL-27 antagonist. IL-27R alpha can be used as an independent prognostic aGVHD biomarker. IL-27/IL-27R alpha also plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production. IL-27/IL-27RA signaling can suppress the expression of inflammatory cytokines, IL-6 and IL-8, induced by LPS stimulation, leading to phosphorylation of STAT1 and STAT3.
蛋白编号:Q6UWB1 (M1-R514)
基因 ID:9466
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-27 受体 | 白介素-27 受体 α
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-27 Receptor | IL27RA
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