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MCE 国际站:IFN-gamma R1/CD119 Protein, Mouse (HEK293, Fc)
IFN-gamma R1,IFN-gamma 受体的亚基之一,是 IFN-γ 的结合受体。IFN-gamma R1 可以与 IFN-gamma R2 结合形成功能性受体。与配体 IFN-γ 结合后,IFN-gamma R1 和 IFN-gamma R2 寡聚化并发生磷酸化。然后,JAK1 和 JAK2 发生磷酸化并激活,STAT1 被募集到受体复合物附近。磷酸化的 STAT1 易位至细胞核,从而调节 IFN-反应性的基因 (例如 CD54) 的表达。FN-gamma R1/CD119 Protein, Mouse (HEK293, Fc) 是一种由 HEK293 细胞产生的重组小鼠 IFN-gamma R1 (M1-D253),C 端带有 hFc 标签。
Synonyms: Interferon gamma receptor 1; IFN-gamma-R1; CD119; Ifngr1; Ifngr
Species: Mouse
Source: HEK293
研究背景:IFN-gamma R1 (CD119), one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R1 is constitutively expressed on the surface of almost all cells.
IFN-gamma R1 can associate with IFN-gamma R2 to form a functional receptor. Upon binding with IFN-gamma, IFNγR1 and IFNγR2 oligomerize and transphosphorylate. Then, JAK1 and JAK2 are phosphorylated and activated, and STAT1 is recruited to the receptor complex. The phosphorylation of IFNγR1 creates a docking site for STAT1 and leads to the phosphorylation of STAT1. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54). IFN-gamma R1 deficiencies are associated with immune responses mediated by IFN-γ, and increased susceptibility to infections. IFN-gamma R1 signaling pathway is important in activating cancer cell death and inhibiting cancer progression
Mouse IFN-gamma R1 consists of extracellular domain (A26-S254), helical domain (I255-Y275), and cytoplasmic domain (W276-S477). The sequence of amino acids in IFNAR1 differs in different species. Mouse IFN-gamma R1 shares 50% aa sequence identity with human.IFN-gamma R1 plays a critical role in antimicrobial, antiviral, and antitumor responses.
蛋白编号:P15261 (M1-D253)
基因 ID:15979
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素-γ 受体 | 干扰素-γ 受体 1
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-gamma Receptor | IFN-gamma R1
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