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BMP-1 Protein, Human (His)

MCE 国际站：BMP-1 Protein, Human (His)

骨形态发生蛋白 1 (BMP-1) 又称金属蛋白酶，属于 BMP-1/tolloidlike 蛋白酶 (BTP) 家族。BMP-1 也是一种标志性的细胞外基质 (ECM) 蛋白，与乳腺肿瘤的高转移潜力相关。BMP-1 能够加工生长因子，包括 TGFβ、BMP2、BMP4和GFD8，调节形态发生，并在细胞外间隙介导 I 型前胶原 COOH 羧基末端前肽 (CICP) 的裂解。人 BMP-1 蛋白全长 392 个氨基酸 (M1-R392)，具有 4 个糖基化片段。人 BMP-15 蛋白全长 986 个氨基酸 (M1-K986)，具有 4 个糖基化片段。重组人 BMP-1 蛋白 (His) 全长 866 个氨基酸 (A121-K986)，由 E. coli 大肠杆菌表达，带有 N 端 *His 标签。

Synonyms: BMP 1; BMP-1; BMP1; BMP1_HUMAN; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; OI13; PCOLC; PCP; PCP2; Procollagen C endopeptidase; Procollagen C proteinase; Procollagen C-proteinase; TLD; Tolloid; Drosophila; homolog of

Species: Human

Source: E. coli

研究背景：Bone morphogenetic protein 1 (BMP-1) also known as metalloprotease, belonging to the BMP-1/tolloidlike proteinases (BTP) family. BTPs are known to be involved in the control of muscle growth and homeostasis and in wound healing and tissue repair, and BMP-1 is a signature extracellular matrix (ECM) proteins associated with the high metastatic potential of breast tumors. BMP-1 regulates morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8.
BMP1 is the dominant C-proteinase in postnatal lung fibroblasts and mediates cleavage of COOH-terminal propeptide of type I procollagen (CICP) with the main action site of extracellular space.
BMP1 maintains appropriate levels of procollagen I and its activated products, acts as an essential part for maintaining periodontal homeostasis and normal cementum formation.
The cleavage of thrombospondin-1 (TSP-1), an ECM protein classified as “matricellular” for its ability to regulate cell-matrix interactions, results BMP-1 overexpression. However BMP-1 can both trigger the disruption of cell adhesion and stimulate TGF-β signaling in TSP-1-rich microenvironments, which promote the differentiation of primary human keratocytes into myofibroblasts.
Thereby, BMP1 participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis.
Mutations of BMP1 gene cause osteogenesis imperfecta in human, a bone disorder characterized by brittle bones that are prone to fracture, or phenotypes of periodontal disease and skin fragility in mice.
BMP1-3 is a novel systemic regulator of bone repair. BMP1-3 isoform of the BMP-1 gene circulates in the human plasma and enhances bone healing. In vitro BMP1-3 increases the expression of collagen type I and osteocalcin in MC3T3-E(1) osteoblast like cells, and enhances the formation of mineralized bone nodules from bone marrow mesenchymal stem cells.
BMP-1 is widely found in different animals, while the sequence in human is highly similar with rat (96.54%), and mouse (96.34).

蛋白编号：P13497 (A121-K986)

基因 ID：649

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  骨形态发生蛋白 1

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  Bone Morphogenetic Protein 1

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