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Cathepsin D Protein, Mouse (HEK293, His)

MCE 国际站：Cathepsin D Protein, Mouse (HEK293, His)

Cathepsin D Protein, Mouse (HEK293, His)是一个约 56.0 kDa 的小鼠组织蛋白酶 D，带有 His 标签。Cathepsin D 是胃蛋白酶家族的溶酶体天冬氨酸蛋白酶。

Synonyms: rMuCathepsin D, His; Cathepsin D; CTSD; CPSD

Species: Mouse

Source: HEK293

Biological Activity: Measured by its ability to cleave a peptide substrate, Mca-PLGL-Dpa-AR-NH2. Read at excitation and emission wavelengths of 320 nm and 405 nm (top read). The specific activity is 5026.88 pmol/min/µg, as measured under the described conditions.

研究背景：Cathepsin D, a lysosomal aspartic protease, belongs to the pepsin family. Mouse Cathepsin D consists of a signal peptide (residues 1?20), a propeptide (residues 21?64), and a mature chain (residues 65?410) (1?3). Cathepsin D is expressed in most cells and overexpressed in in some cancer (breast, melanoma, ovary, etc.). Cathepsin D increases the incidence of clinical metastasis involves increased cell growth and decreased contact inhibition rather than escape of cancer cells through the basement membrane.
Cathepsin D acts as a protease following its activation at an acidic pH, or as a ligand of different membrane receptors at a more neutral pH.

蛋白编号：P18242 (I21-L410)

基因 ID：13033

产品分类：酶和调节子  |  组织蛋白酶  |  组织蛋白酶 D  |  酶和调节子  |  水解酶

Categories：Enzymes & Regulators  |  Cathepsin  |  Cathepsin D  |  Enzymes & Regulators  |  Hydrolases (EC 3)

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