MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:IFN-alpha/beta R2 Protein, Human (217a.a, HEK293, His)
IFN-alpha/beta R2,IFN-α/β 受体的亚基之一,是 I 型 IFN 受体。IFNAR1 可与 IFNAR2 形成异二聚体受体并与 type I 型 IFNs 结合。IFN-alpha/beta R2 也可与 JAK1 相互作用并导致 IFNAR 和 STAT 蛋白的酪氨酸磷酸化。在被这些 IFN 激活后,IFNAR1 和 IFN-alpha/beta R2 会发生构象变化以促进下游信号事件级联反应的发生,包括 Tyk2 和 JAK1、STAT1 和 STAT2 的磷酸化。(I27-K243) 是一种由 HEK293 细胞产生的重组人 IFN-alpha/beta R2 (I27-K243),C 端带有 6*His 标签。
Synonyms: Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB
Species: Human
Source: HEK293
Biological Activity: Immobilized Human IFNA2 at 10 μg/mL (100 μL/well) can bind IFNAR2. The ED50 for this effect is 568.9 ng/mL.
研究背景:IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 is expressed on peripheral blood B cells and monocytes, and mediates differentiation and activation of these cells.
IFN-alpha/beta R2 forms the heterodimeric receptor (IFN-α/β receptor) together with IFNAR1. IFNs such as IFN-α/-β can induce association of the IFNAR1 and IFN-alpha/beta R2, which makes JAK1 and TYK2 form a functional signaling unit. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events. The signaling events includes the phosphorylation of Tyk2 and JAK1, the signal transducers and activators of transcription STAT1 and STAT2, and the formation of the IFN-stimulated gene factor 3 (ISGF3) complex which consists of phosphorylated STAT1 and STAT2 and IRF9. IFNAR2 is critical for anti-viral immunity.
Human IFN-alpha/beta R2 consists of extracellular domain (I27-K243), helical domain (I244-L264), and cytoplasmic domain (K265-R515). The sequence of amino acids in IFN-alpha/beta R2 differs in different species. Human IFN-alpha/beta R2 shares <50% aa sequence identity with mouse.
IFN-alpha/beta R2 mediates IFN-induced tyrosine phosphorylation of the IFNARs and STAT proteins, and activates the JAK-STAT signaling cascade
蛋白编号:P48551 (I27-K243)
基因 ID:3455
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素-α/β 受体 | Ⅰ型干扰素受体 2
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-α/β Receptor | IFN-alpha/beta R2
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。