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MCE 国际站:IL-20R beta Protein, Mouse (HEK293, His)
IL-20R beta 蛋白 (IL20RB) 是 IL-20 受体的 β 亚基,与不同亚基蛋白形成功能性异二聚体,参与 STAT3 通路激活。IL-20RA/IL-20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体,而 IL-22RA1/IL-20RB 二聚体是 IL-20 和 IL-24的受体。IL-20R alpha 蛋白由 311 个氨基酸 (M1-S311) 组成,具有跨膜结构域 (234-254 a.a.)。重组人 IL-20R beta 蛋白 (HEK293, Fc),由 HEK293 细胞表达,带有 C 末端 hFc 标签。
Synonyms: Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
Species: Mouse
Source: HEK293
研究背景:IL-20R beta (IL-12RB), also known as a beta subunit of IL-20 receptor (IL-20RB), belongs to the type II cytokine receptor family. IL-20R beta is widely expressed with highest levels in skin and testis and highly expressed in psoriatic skin.
IL-20R beta forms functional heterodimers with different subunit protein. IL-20R beta serves as the receptor for IL-19, IL-20 and IL-24 by dimerizing with IL20RA, however serves as the receptor for IL-20 and IL-24 by dimerizing with IL-22RA1.
IL-20RB/IL-20RA and IL-20RB/IL-22RA1, act function by binding IL-20, and then stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line.
However, the expression of both IL-20RB/IL-20RA is found to be upregulated in psoriatic skin lesions on keratinocytes.
IL-20RB/IL-20RA and IL-20RB/IL-22RA1 bind to IL-24, induce rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation.
The sequence of amino acids in IL-12 beta proteins of mouse is very different from human (64.64%).
蛋白编号:NP_001028715 (M1-S225)
基因 ID:213208
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-20 受体 | 白介素-20 受体 β
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-20 Receptor | IL-20R beta
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