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MIP-4/CCL18 Protein, Human (His)

MCE 国际站：MIP-4/CCL18 Protein, Human (His)

MIP-4/CCL18 Protein, Human (His) 是一种 CC 趋化因子配体，可以与 PITPNM3、GPR30 和CCR8 受体结合，也可以作为中性的 CCR3 拮抗剂，介导炎症、自身免疫以及癌症发生。MIP-4/CCL18 Protein, Human (His) 是一种由 E. coli 表达的重组人MIP-4/CCL18(A21-A89) 蛋白，N 端带有 his标签。

Synonyms: C-C motif chemokine 18; AMAC-1; DC-CK1; MIP-4; CCL18; PARC; SCYA18

Species: Human

Source: E. coli

Biological Activity: The biological activity determined by a chemotaxis bioassay human T-lymphocytes. The ED₅₀ this effect is 2.763 ng/mL, corresponding to a specific activity is 3.62×10⁵ U/mg.

研究背景：CCL18, also known as macrophage inflammatory protein-4 (MIP-4), pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1) and alternative macrophage activation-associated CC chemokine-1 (AMAC-1), is a small cell factor of the CC chemokine family. CCL18 is located on chromosome 17 in the human gene and has the highest amino acid identity (65%) with CCL3, encoding an 89 amino acid long protein with a 20 amino acid long peptide signal sequence at the N' terminus that signals its secretion and is cleaved in the endoplasmic reticulum into a 69 amino acid long mature protein. CCL18 is mainly produced by antigen-presenting cells of the innate immune system, including dendritic cells, monocytes and macrophages, but not in T and B cells. In macrophages, CCL18 is induced by the Th2 cytokines IL-4 and IL-13, which program macrophages to differentiate into AAMs, which contribute to the healing phase of acute inflammatory responses and to tissue remodeling and fibrosis in chronic inflammatory diseases.CCL18 can bind to PITPNM3, GPR30, and CCR8 receptors, where CCL18 binding to CCR8 binding induces chemotaxis of Th2 cells. In addition, CCL18 can also act as a neutral CCR3 antagonist and participate in the inflammatory response. It has been shown that CCL18 and its receptor CCR8 are co-expressed in diseased human tissues during active eosinophilic inflammation. In parallel, enhanced production of CCL18 has been demonstrated in a variety of diseases, including various malignancies and inflammatory joint, lung and skin diseases.

蛋白编号：P55774 (A21-A89)

基因 ID：6362

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL18

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL18

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