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MCE 国际站:Animal-Free BMP-8a Protein, Human (His)
BMP-8 是一种多效配体蛋白,作为生殖系统调节因子富集于卵巢。BMP-8 由一对 BMP8A 和 BMP8B 基因编码,属于 TNF-β 家族。BMP-8A 激活颗粒细胞中的 SMAD1/5/8 和 SMAD2/3 通路,抑制促性腺激素诱导的孕酮产生和激素生成相关基因的表达。BMP-8A 还参与癌细胞的 Nrf2 磷酸化以促进癌细胞生存和耐药。人的 BMP-8a 蛋白全长 402 个氨基酸,包含 2 个糖蛋白域。重组人 BMP-8a 蛋白 (Animal-Free, His) 是无动物源的重组人 BMP-8a 蛋白,由 E. coli 大肠杆菌表达,全长 139 个氨基酸 (A264-H402),带有 C 端 His 标签。
Synonyms: BMP-8; OP-2; Osteogenic Protein-2
Species: Human
Source: E. coli
Biological Activity: Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is 10-19.4 ng/mL.
研究背景:"BMP-8 is a pleiotropic ligand protein act as a reproductive system regulator. BMP-8 is encoded by a pair of genes, BMP8A and BMP8B, belonging to TNF-β family. GMP-8 initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Both BMP8A and BMP8B are enriched in the ovary and activate canonical BMP signaling in different cells, including spermatogonia, P19 and 293T cells. BMP-8 is widely found in different animals, while the sequences of BMP-8A and BMP-8B in human are highly different from Mouse with similarities of 85.96% and 74.44%, respectively.
As for BMP8A, which is mainly secreted by granulosa cells within growing ovarian follicles. BMP8A encodes a secreted ligand of the TGF-β superfamily of proteins to bind various TGF-beta receptors, leading to recruitment and activation of SMAD family transcription factors and regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. BMP-8A protein activates the SMAD1/5/8 and the SMAD2/3 pathways in granulosa cells, to inhibit gonadotropin-induced progesterone production and steroidogenesis-related gene expression. BMP8A protein plays a role in development of the reproductive system by sustaining spermatogenesis by activating both SMAD1/5/9 and SMAD2/3 in spermatogonia. BMP-8A protein also activates Nrf2 and Wnt pathways in clear cell renal cell carcinoma (ccRCC) to promote cell proliferation and inhibit apoptosis.
As for BMP8B, which protein is secreted by brown/beige adipocytes and enhances energy dissipation, serves as an interconnected regulator of neuro-vascular remodeling in AT and is potential targets in obesity. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Thus BMP8B contributes to adrenergic-induced remodeling of the neuro-vascular network in adipose tissue, therefore through the adipocytes to 1) secrete neuregulin-4 (NRG4), which promotes sympathetic axon growth and branching in vitro, and 2) induce a pro-angiogenic transcriptional and secretory profile that promotes vascular sprouting. BMP8B also involve in activation of caspase-3 and -9, and apoptosis to inhibit pancreatic cancer cell growth.
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蛋白编号:AAP74559.1 (A264-H402)
基因 ID:353500
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 骨形态发生蛋白 | 骨形态发生蛋白 8a | 无动物成分重组蛋白
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Bone Morphogenetic Proteins (BMPs) | BMP-8a | Animal-free Recombinant Proteins
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