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KGF-2/FGF-10 Protein, Human (169a.a)

MCE 国际站：KGF-2/FGF-10 Protein, Human (169a.a)

KGF-2/FGF-10 Protein, Human (159a.a)是一种肝素结合蛋白，与 FGF2 IIIb 和 FGFR1III-b 受体结合，能够促进上皮细胞的生长、增殖、分化，并且增强角膜伤口的愈合。

Synonyms: rHuKGF-2/FGF-10; Fibroblast Growth Factor-10

Species: Human

Source: E. coli

Biological Activity: Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 18-35.64 ng/mL, corresponding to a specificactivity is >2.806×10^4 Unit/mg.

研究背景：Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a soluble 170-amino-acid polypeptide secreted by fibroblasts and endothelial cells acting primarily on epithelial cells. Its functions mainly mediated by FGF-2 IIIb receptor, a transmembrane receptor, expressed exclusively by epithelial cells. KGF-2 promotes the growth, proliferation, and differentiation of epithelial cells, with promising effects in treating epithelial damage. KGF-2 enhances corneal wound healing in a rabbit model of carbon dioxide laser-induced corneal injury. Keratinocyte growth factor-2 (KGF-2) is a 20-kD heparin-binding protein, and also binds to FGFR1III-b, which may explain the severely impaired lung development of FGF-10 null mice.

蛋白编号：O15520 (L40-S208)

基因 ID：2255

产品分类：细胞因子和生长因子  |  FGF 家族  |  成纤维细胞生长因子  |  成纤维细胞生长因子 10

Categories：Cytokines and Growth Factors  |  FGF Family  |  Fibroblast Growth Factor  |  FGF-10

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