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MCE 国际站:I-TAC/CXCL11 Protein, Human
CXCL11,也称为 IFN 诱导型T 细胞 α-趋化因子 (I-TAC),属于 ELR 阴性 CXC 趋化因子家族。CXCL11 由多种细胞在干扰素 (IFN) 刺激后产生,包括白细胞、成纤维细胞和内皮细胞。CXCL11 通过结合CXCR3 发出信号。CXCL11 与多效性功能相关,包括趋化性迁移、调节细胞增殖和自我更新、增加细胞粘附和调节血管抑制作用。I-TAC/CXCL11 Protein, Human 由 73 个氨基酸(F22-F94) 组成,在大肠杆菌中表达产生。
Synonyms: rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11
Species: Human
Source: E. coli
Biological Activity: 1. The ED50 is <2.5 μg/mL as measured by CHO cells, corresponding to a specific activity of >400 units/mg.
2. The biological activity determined by a chemotaxis bioassay using activated human T-lymphocytes. The ED50 for this effect is 1.98 ng/mL in the presence of 1 ng/mL human IL-2, corresponding to a specific activity is 5.05×10^5 U/mg.
研究背景:CXCL11 is mainly expressed in the lung, pancreas, thymus, peripheral blood leukocytes, spleen, and liver and is expressed at lesser levels in the intestine, placenta, and prostate. CXCL11 is located on human chromosome 4 and is mainly secreted by cancer cells, leukocytes, monocytes, dendritic cells, endothelial cells, and fibroblasts. CXCL11 attracts activated lymphocytes and NK cells to inflamed tissue and to tumors and inhibits the generation of novel blood vessels essential for tumor growth and tissue repair.
CXCL11 which can bind to two different chemokine receptors, CXCR3 and CXCR7. CXCL11 is characterized by the presence of 1 amino acid in between the 2 NH2-terminal cysteines. CXCL11 is usually expressed at low levels in homeostatic conditions, but is upregulated during cancer or infectious disease processes. CXCL11 is mainly induced by IFN-γ and IFN-β and is weakly induced by IFN-α. CXCL11 has potent chemoattractant activity for IL-2 activated T cells and transfected cell lines expressing CXCR3, but not freshly isolated T cells, neutrophils or monocytes. Simultaneous stimulation of fibroblasts or endothelial cells with IFN-γ and interleukin-1β or the TLR3 ligand double-stranded RNA resulted in a synergistic increase of CXCL11 production. In leukocytes, bacterial LPS and PGN even inhibited interferon-induced CXCL11 production. CXCL11 attracts activated T-helper 1 (Th1) lymphocytes and natural killer (NK) cells. Furthermore, CXCL11 can bind to CXCR7, which is associated with invasiveness and reduces apoptosis of tumor cells.
The diverse functions of CXCL11 include inhibiting angiogenesis, affecting the proliferation of different cell types, playing a role in fibroblast directed carcinoma invasion, increasing adhesion properties, suppressing M2 macrophage polarization, and facilitating the migration of certain immune cells.
蛋白编号:O14625 (F22-F94)
基因 ID:6373
产品分类:细胞因子和生长因子 | 趋化因子 | CXC 趋化因子 | CXC 趋化因子配体 11
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CXC Chemokines | I-TAC/CXCL11
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