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MCE 国际站:SDF-1 alpha/CXCL12 Protein, Mouse
SDF-1 alpha (基质细胞衍生因子 1α,SDF-1α) 是缺乏 ELR 结构域的趋化因子 α 亚家族的成员。SDF-1α 作为 T 和 B 淋巴细胞和单核细胞的趋化剂。SDF-1α 是CXCR4 的配体。SDF-1α/CXCR4 信号介导许多生理过程,包括细胞运输、血管生成、胚胎发生、肿瘤侵袭和转移。它还控制归巢到骨髓的造血干细胞的趋化性。SDF-1 alpha/CXCL12 Protein, Mouse 在大肠杆菌中表达产生,由 68 个氨基酸 (K22-K89) 组成。
Synonyms: rMuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF
Species: Mouse
Source: E. coli
Biological Activity: Full biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml. Or measured by its ability to chemoattract IL-2-activated human T cells. The ED50 for this effect is approximately 31.38 ng/mL, corresponding to a specific activity is 3.19×10^4 U/mg.
研究背景:Stromal cell-derived factor-1 (SDF-1), an important member of the chemokine family, is expressed in two subtypes, SDF-1α and SDF-1β, with SDF-1α being the main subtype. SDF-1α is widely present in many tissues and organs of the human body, such as the lymph nodes, bone marrow, liver, lung, muscle, small intestine, kidney, and brain, and can sustainably exist in these organs and tissues. Studies have shown that SDF-1α plays an important role in the physiological mfunctions of migration, distribution, development, differentiation, and apoptosis of various cells. Moreover, SDF-1α plays a key role in the pathological process of some diseases, such as inflammation, tumor formation and metastasis, pathogen infection, and wound repair.
SDF-1 has three isoforms, α, β, and γ, which are different at the splicing level, not at the transcriptional level. The analysis of the genomic structure of SDF-1 in human and mouse revealed two isoforms, SDF-1α and SDF-1β, which are encoded by a single gene and result from alternative splicing. SDF-1α comprises 3 exons and encodes a protein of 89 amino acids whereas SDF-1β consists of 4 exons and encodes a protein of 93 amino acids. Both isoforms are highly similar regarding their sequences with the only difference of 4 additional amino acids at the C-terminus of SDF1β. In adult rat brain, SDF-1α is the predominant one, present in astrocytes, microglia, as well as in neurons. SDF-1α is found positive in normal cholinergic neurons, such as in the medial septum and substantia innominata, and in dopaminergic neurons, such as in the substantia nigra (SN) pars compacta and the ventral tegmental area. SDF-1α is the only known ligand for CXCR4. CXCR4 is also a target for human immunodeficiency virus (HIV) binding.
In vitro and in vivo studies using ischemic reperfusion models and a pretreatment with SDF-1α results in decreased infarct size and increases resistance to hypoxic damage and apoptotic cell death via activation of ERK-1/2 and AKT phosphorylation. The SDF-1α/CXCR4 signaling maintains central nervous system homeostasis through the interaction with the neurotransmitter and neuropeptide systems, the neuroendocrine systems. An increasing number of animal experiments have shown that SDF-1α can enhance the migration of BMSCs, mobilize BMSCs to diseased areas, and promote their proliferation and differentiation.
蛋白编号:P40224 (K22-K89)
基因 ID:20315
产品分类:细胞因子和生长因子 | 趋化因子 | CXC 趋化因子 | CXC 趋化因子配体 12 | 趋化因子 | CXC 趋化因子 | CXC 趋化因子配体 12 | 重组人基质细胞衍生因子-1α
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CXC Chemokines | SDF-1/CXCL12 | Chemokine & Receptors | CXC Chemokines | SDF-1/CXCL12 | CXCL12/SDF-1 alpha
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