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MCE 国际站:DcR3/TNFRSF6B Protein, Human (sf9, hFc)
DcR3 是肿瘤坏死因子 (TNF) 受体超家族的分泌成员,被认为是一种重要的抗凋亡因子,显著参与各种炎症和肿瘤疾病。DcR3 可以中和细胞毒配体 TNFS14/LIGHT、TNFSF15 和 TNFSF6/FASL,以对抗凋亡。DcR3 通过 DcR3/STAT1/IRF1 反馈环调节肿瘤发生和转移。DcR3/TNFRSF6B Protein, Human (sf9, hFc) 全长 300 个氨基酸 (M1-H300),由 sf9 昆虫细胞表达,带有 C 端 hFc标记。
Synonyms: Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; TNFRSF6B; DCR3; TR6
Species: Human
Source: Sf9 insect cells
Biological Activity: Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells and the ED50 for this effect is typically 0.5-3 μg/mL in the presence of 200 ng/mL human Fas ligand.
研究背景:Decoy Receptor 3 (DcR3), a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily, neutralizes three different TNF ligands/pro-apoptotic molecules: FasL, LIGHT, and TL1A. Each of these ligands engages unique signaling receptors which direct distinct and critical immune responses. Dcr3 has competitive binding with the functional receptors to the respective cytokines (Fas for FasL, DR3 for TL1A, and LTbR and herpesvirus entry mediator/HVEM for LIGHT), thus preventing downstream pro-apoptotic signaling. DcR3 is encoded by the Tnfrsf6b gene, which does not encode a cytoplasmic or transmembrane segment, resulting in an obligate secreted protein of 300 amino acids including the signal peptide. However, mouse and rat genomes lack a Tnfrsf6b gene. DcR3 is overexpressed in a wide variety of malignancies and is correlated with tumorigenesis and progression. Therefore, it has been considered a potential biomarker to predict cancer invasion and progression of inflammation. Specifically, DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in human colorectal cancer (CRC). In addition, it increases the expression levels of several components of the PI3K/AKT/GSK-3β/β-catenin signaling pathway, such as p-AKT, GSK-3β, p-GSK-3β and β-catenin. Additionally, DcR3 also enhances the expression of N-cadherin and Vimentin and decreases the expression of E-cadherin. DcR3 also promotes proliferation and invasion of pancreatic cancer via a DcR3/STAT1/IRF1 feedback loop. It promotes the phosphorylation of signal transducers and activators of transcription 1 (STAT1), leading to a dramatic increase in interferon regulatory factor 1 (IRF1). IRF1 then increased the transcriptional activity of DcR3, forming a positive feedback loop to reinforce DcR3 expression. The homology of human DcR3 protein is low with that of other animals, and the sequence similarity with rats, mice and pigs is 20.49%, 20.82% and 20.00%, respectively.
蛋白编号:O95407 (M1-H300)
基因 ID:8771
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | 诱骗受体 3
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | Decoy Receptor 3
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