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MCE 国际站:AGER Protein, Human (HEK293, His)
AGER Protein, Human (HEK293, His)是带有 C 末端 His 标签的人重组 AGER,通过哺乳动物表达系统表达,并表达编码Ala23-Ala344的靶基因。
Synonyms: rHuAGER, His; RAGE; AGER
Species: Human
Source: HEK293
研究背景:AGER (Advanced glycosylation end product-specific receptor), a member of the immunoglobulin superfamily of cell surface molecules, is a transmembrane signal transduction receptor with a number of ligands, including alarmins that can initiate and perpetuate immune responses. AGER naturally exists in two forms that are full-length membrane-bound and truncated (soluble). The human AGER is a highly polymorphic gene with more than 190 SNPs mapped to its locus on the 6p21.3 chromosome. AGER interacts with a broad spectrum of ligands and multiple signaling pathways, such as those activated by the high mobility group box 1 (HMGB1) protein (a non-canonical ligand of AGER). AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes.
蛋白编号:Q15109 (A23-A344)
基因 ID:177
产品分类:受体蛋白
Categories:Receptor Proteins
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