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MCE 国际站:Alkaline Phosphatase/ALPL Protein, Human (HEK293, His)
Alkaline Phosphatase/ALPL Protein, Human (HEK 293, His) 是一种细胞表面同源二聚体磷酸水解酶,在骨骼、肝脏、肾脏和发育中的牙齿中大量表达。
Synonyms: rHuAlkaline phosphatase, tissue-nonspecific isozyme/ALPL, His; Alkaline Phosphatase; Tissue-Nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL
Species: Human
Source: HEK293
Biological Activity: Measured by its ability to cleave the substrate p-nitrophenylphosphate.The specific activity is 157 nmol/min/μg.
研究背景:Hypophosphatasia is the inborn error of metabolism characterized by low serum alkaline phosphatase activity (hypophosphatasaemia). This biochemical hallmark reflects loss-of-function mutations within the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a cell-surface homodimeric phosphohydrolase that is richly expressed in the skeleton, liver, kidney and developing teeth. In hypophosphatasia, extracellular accumulation of TNSALP natural substrates includes inorganic pyrophosphate, an inhibitor of mineralization, which explains the dento-osseous and arthritic complications featuring tooth loss, rickets or osteomalacia, and calcific arthopathies.
蛋白编号:P05186 (L18-S502)
基因 ID:249
产品分类:酶和调节子 | 磷酸酶 | 碱性磷酸酶 | 酶和调节子 | 水解酶
Categories:Enzymes & Regulators | Phosphatase | Alkaline Phosphatase | Enzymes & Regulators | Hydrolases (EC 3)
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