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gp130/IL6ST Protein, Human (HEK293)

MCE 国际站：gp130/IL6ST Protein, Human (HEK293)

Glycoprotein 130 (gp130) 是一种跨膜蛋白，是白细胞介素 6 (IL-6) 家族的常见信号转导受体亚基。gp130 抑制细胞生长和迁移，降低 IL-6 诱导的 STAT3 磷酸化，降低 IL-6 诱导的 Ki67 增加。gp130 具有抗肿瘤、抗炎和抗伤害活性。gp130/IL6ST Protein, Human (HEK293) 是重组蛋白, 由 618 个 (M1-I618) 氨基酸组成，在 HEK293 细胞中表达。

Synonyms: Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST

Species: Human

Source: HEK293

研究背景：Glycoprotein 130 mRNA is ubiquitously expressed in the human body,exhibiting highest levels in saphenous vein, pericardium, ovary, omental adipose tissue, peritoneum, spleen lymphnodes, and trigeminal ganglia. And gp130 expression is significantly increased in adult organs compared to fetal organs. Moreover, gp130 is highly expressed in multiple types of cancers compared to normal tissues.
The amino acid sequence of human gp130 protein has low homology between mouse and rat gp130 protein.
gp130 signaling is initiated when autocrine or paracrine cyto-kines induce the dimerization of gp130 and an α-receptor subunit to form the receptor complex, leading to185the activation of downstream signaling cascades, such as the JAK/STAT, the PI3K/Akt, and the Ras/Raf/Mek/Erk1/2MAPK pathways. The activation of JAK/Stat3 pathway induces its target gene expression, resulting in cell growth and proliferation (cyclin D, CDC25 A, c-Myc, survivin), survival (survivin, Bcl-2, Bcl-X_L), angiogenesis (VEGF), and cell migration (MMP-2, MMP-7, and MMP-9). gp130 is a IL-6 antagonist shows anti-tumor, anti-inflammation and antinociceptive activity. gp130 decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67.

蛋白编号：P40189 (M1-I618)

基因 ID：3572

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-6 受体  |  糖蛋白 130  |  CD 抗原  |  上皮细胞 CD 蛋白  |  gp130/CD130  |  CD 抗原  |  内皮细胞 CD 蛋白  |  gp130/CD130  |  细胞因子和生长因子  |  神经营养因子  |  糖蛋白 130

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-6R  |  Glycoprotein 130 (gp130)  |  CD Antigens  |  Epithelial cell CD Proteins  |  gp130/CD130  |  CD Antigens  |  Endothelial cell CD Proteins  |  gp130/CD130  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  Glycoprotein 130 (gp130)

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