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MCE 国际站:MIP-5/CCL15 Protein, Human
MIP-5/CCL15 Protein, Human 是一种 CC 趋化因子,对髓细胞如树突状细胞、单核细胞、中性粒细胞和一些 T 淋巴细胞具有很强的趋化性。MIP-5/CCL15 Protein, Human 可以与趋化因子受体 CCR1、CCR3 结合,在白细胞招募和炎症性疾病的发展中起着关键作用。MIP-5/CCL15 Protein, Human 是一种由 E. coli 表达的重组人 MIP-5/CCL15(Q22-I113)。
Synonyms: rHuMIP-5/CCL15; C-C motif chemokine 15; HCC-2; SCYA15; NCC3
Species: Human
Source: E. coli
Biological Activity: 1. The ED50 is <2 μg/mL as measured by CHO cells transfected with human CCR1, corresponding to a specific activity of >500 units/mg.
2. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED50 this effect is 6.04 ng/mL, corresponding to a specific activity is 1.56×10^5 U/mg.
研究背景:CCL15, also known as macrophage inhibitory protein 5 (MIP-5), leukocyte chemokine 1 (Lkn-1) and human CC chemokine 2 (HCC-2), is a small cytokine belonging to the CC chemokine family, a cluster of chemokines located on human chromosome 17 with a gene sequence similar to CC motif chemokine ligand 5 (CCL5) and CC motif chemokine ligand 3 ( CCL3). CCL15 can be expressed in certain leukocytes and macrophages in the liver, small intestine, colon, and lung. CCL15 acts as a chemoattractant for neutrophils, monocytes and lymphocytes and can bind to chemokine receptors CCR1 and CCR3, of which CCR3 is the major receptor for human eosinophils and plays an important role in the migration of monocytes, lymphocytes and neutrophils. Meanwhile, CCL15 plays an effector molecule role in the regulation of hematopoietic cells and host defense. Recombinant human CCL15 is also the most abundant chemokine in follicular thyroid cancer (FTC). CCL15 has been reported to be elevated in bronchoalveolar lavage fluid (BALF) from patients with stage III nodular disease and in peripheral blood from patients with severe persistent asthma, contributing to the severity and persistence of the disease by targeting its receptors (especially CCR1) in an autocrine manner.
蛋白编号:Q16663 (Q22-I113)
基因 ID:6359
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL15
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | CCL15
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