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MCE 国际站:HCC-4/CCL16 Protein, Human
HCC-4/CCL16 Protein, Human 是一种 CC 趋化因子,能够特异性的吸引淋巴细胞、树突状细胞核单核细胞,增加它们的粘附性并具有骨髓抑制活性。HCC-4/CCL16 Protein, Human 可以与 CCR1、CCR2、CCR5 和 CCR8 相互作用,介导炎症及癌症反应。HCC-4/CCL16 Protein, Human 是一种由 E. coli 表达的重组人 HCC-4/CCL16 (Q24-Q120)。
Synonyms: rHuHCC-4/CCL16; C-C motif chemokine 16; SCYA16
Species: Human
Source: E. coli
Biological Activity: 1. Full biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/mL.
2. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED50 this effect is 1.25 μg/mL, corresponding to a specific activity is 800 U/mg.
研究背景:CCL16, also known as CC chemokine 4, liver expressed chemokine (LEC) and monotactin-1 (MTN-1), is a small cytokine belonging to the CC chemokine family, a cluster of chemokines located on human chromosome 17. CCL16 is also a ligand for the histamine H4 receptor. CCL16 can chemotacticize monocytes and lymphocytes but not neutrophils. Recent studies have shown that CCL16 increases tumor rejection, antigen presentation by macrophages, and angiogenic activity of vascular endothelial cells. On the other hand, CCL16 may also enhance the anticancer effects of cytotoxic T cells and dendritic cell (DC) lymphocytes.
蛋白编号:O15467 (Q24-Q120)
基因 ID:6360
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL16
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | CCL16
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