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IL-17RA Protein, Human (HEK293, Fc)

MCE 国际站：IL-17RA Protein, Human (HEK293, Fc)

IL-17RA (白细胞介素 17 受体 A) 是 IL-17A 和 IL-17F 的受体，是一种 I 型膜糖蛋白。它普遍表达并表现出广泛的组织分布，并在许多炎症和自身免疫性疾病中发挥作用。IL-17RA 是IL-17 家族其他成员的共同受体亚基。IL-17RA 与 IL-17RC 结合形成 IL-17A 和 IL-17F 的信号受体复合物。IL-17RA Protein, Human (HEK 293, Fc) 在 HEK293 细胞中产生，由 288 个氨基酸(L33-W320) 组成，其 C 末端带有 Fc 标签。

Synonyms: Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD_antigen; CD217; IL17RA; IL17R

Species: Human

Source: HEK293

研究背景：Interleukin-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that binds interleukin 17. IL-17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous and is a common co-receptor subunit for other members of the IL-17 family. The IL-17RA gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution.
The amino acid sequence of human IL17RA protein has low homology between mouse and rat IL-17A protein.
IL-17A, the prototypic T helper 17 (Th17) cytokine, is important in host defense at mucosal surfaces, but also functions as an important inflammatory mediator involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. IL-17RA offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL-17A activates downstream cellular signaling through IL-17 receptor (IL-17R) complex comprised of the IL-17A receptor (IL-17RA) and IL-17C receptor (IL-17RC) subunits with higher affinity to IL-17RA. The IL-17A/IL-17RA axis has been implicated in the pathogenesis of several acute and chronic airway and lung diseases. However, the association of IL-17RA with other members of the IL-17 receptor family shifts the affinity toward other members of the IL-17 family. Indeed, combination of IL-17RA with IL-17RB binds IL-17E as covalent homodimers. Besides, IL-17RA can also associate with IL-17RE to bind IL-17C as homodimers. However, the involvement of IL-17RA is not compulsory, as IL-17RB forms homodimers to target IL-17B as covalent homodimers.
IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RA involved in antimicrobial host defense and maintenance of tissue integrity. It has been demonstrated in infectious models in which neutrophils are crucial for host defense, that IL-17RA deficiency results in reduced chemokine levels and reduced neutrophil numbers, and increased susceptibility to infection. In addition, IL-17RA is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis.

蛋白编号：Q96F46 (L33-W320)

基因 ID：23765

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-17 受体  |  白介素-17 受体 A  |  CD 抗原  |  上皮细胞 CD 蛋白  |  CD217  |  CD 抗原  |  内皮细胞 CD 蛋白  |  CD217

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-17 Receptor  |  IL-17RA  |  CD Antigens  |  Epithelial cell CD Proteins  |  CD217  |  CD Antigens  |  Endothelial cell CD Proteins  |  CD217

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